Drug Discovery Research Screening Libraries
Selleck Chemical LLC Anti-infection Compound Library 100uL/well
A unique collection of 1415 anti-infection compounds with biological activity of antibacterial,antifungal,antiviral,etc. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Anti-diabetic Compound Library 100uL/well
A unique collection of 150 small molecules for exploring the development of diabetes. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC FDA-approved & Passed Phase I Drug Library 100uL/well
A unique collection of 3176 drugs that are marketed around the world or have passed clinical phase 1 and can be used for high throughput screening (HTS) and high content screening (HCS). *For Research & Development use only. Product is not intended for drug, household, or human consumption.
New England Biolabs, Inc. NEBNext FFPE Library Prep 24
The NEBNext FFPE DNA Library Prep Kit includes the NEBNext FFPE DNA Repair v2 Mix, an optimized cocktail of enzymes designed to repair FFPE DNA, library prep reagents featuring a new polymerase master mix, and a protocol optimized for FFPE DNA. This kit is designed for use with pre-sheared FFPE DNA.
New England Biolabs, Inc. NEBNext Ultrashear FFPE Lib 96
The NEBNext UltraShear FFPE DNA Library Prep Kit includes NEBNext UltraShear, a new solution designed for enzymatic fragmentation of challenging samples; the NEBNext FFPE DNA Repair v2 Mix, an optimized cocktail of enzymes designed to repair FFPE DNA; library prep reagents featuring a new polymerase master mix, and a protocol optimized for FFPE DNA. NEBNext UltraShear further increases library yields and quality, while improving scalability and ease of use.
AdipoGen DRibose
Chemical. CAS 50-69-1. Formula C5H10O5. MW 150.13. Synthetic. Aldopentose monosaccharide that is phosphorylated into D-ribose 5-phosphate by ribokinase. D-ribose-5-phosphate supports the biosynthesis of the amino acids tryptophan and histidine, and is a component in the pentose phosphate pathway. D-ribose is present in all living cells and their microenvironments and is a key component of numerous biomolecules involved in many important metabolic pathways. It also participates in the glycation of proteins producing advanced glycation end products AGEs that lead to cell dysfunction and death. Ribosylation, has been shown to cause protein aggregation in vitro and in vivo. Has demonstrated significant enhancing abilities in replenishing deficient cellular energy levels following myocardial ischemia, improving depressed function in numerous animal investigations and showing cellular protection during oxidative stress.
AdipoGen Nigericin sodium salt
Chemical. CAS 28643-80-3. Formula C40H67NaO11. MW 746.94. Nigericin is an antibiotic, used as a high affinity ionophore for monovalent cations such as H, K, Na, Pb2. It shows antibacterial Gram-positive, antifungal, antitumor and antiviral activity and disrupts membrane potential of mitochondria. It sprimary use is as a NLRP3 activator in inflammasome research.
AdipoGen Lasalocid A sodium salt
Chemical. CAS 25999-20-6. Formula C34H53NaO8. MW 612.8. Synthetic. Ionophore. Potent antibacterial agent and a coccidiostat. Able to form neutral complexes with monovalent and divalent cations and transport them through apolar phase including lipid bilayer membranes. It can transport also larger organic cations, like protonated dopamine.
AdipoGen Hexamethonium bromide
Chemical. CAS 55-97-0. Formula C12H30Br2N2. MW BD9837. Hexamethonium bromide is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as a non-competitive antagonist of nicotinic acetylcholine receptors nAChRs. Formulations containing hexamethonium were previously used in the treatment of hypertension. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation.
AdipoGen C7-L-HSL
Chemical. CAS 177158-20-2. Formula C11H19NO3. MW 213.3. Synthetic. N-Heptanoyl-L-homoserine lactone C7-HSL is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism. The diverse applications of this molecule include regulation of virulence, infection prevention and septicemia in fish.
AdipoGen Glucuronolactone
Chemical. CAS 32449-92-6. Formula C6H8O6. MW 176.12. Synthetic. Naturally occurring carbohydrate derivative that is an important structural component of nearly all connective tissues and is also found in many plant gums. Metabolized to glucaric acid, xylitol, and L-xylulose, and humans may also be able to use glucuronolactone as a precursor for ascorbic acid synthesis. Used as a detoxicant. The liver uses glucose to create glucuronolactone, which inhibits the enzyme B-glucuronidase metabolizes glucuronides, which should cause blood-glucuronide levels to rise. Glucuronides combine with toxic substances, such as morphine and depot medroxyprogesterone acetate, by converting them to water-soluble glucuronide-conjugates which are excreted in the urine. Used as building block and starting reagent for synthesis of drugs, optically active glucopyranoses and long-chain alkyl glucofuranosides.
AdipoGen L-Glutathione reduced
Chemical. CAS 70-18-8. Formula C10H17N3O6S. MW 307.32. Synthetic. Major tripeptide widely distributed in both plants and animals. Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Regulates activity of the redox sensitive transcription factor NF-kappaB. Cytoprotective. Serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. Involved in amino acid transport and maintenance of protein sulfhydryl reduction status. Posseses several metabolic, regulatory and protective functions. Forms disulfide bonds with cysteine residues in proteins.
AdipoGen C10-L-HSL
Chemical. CAS 177315-87-6. Formula C14H25NO3. MW 255.4. Synthetic. N-Decanoyl-L-homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism. The applications of this molecule include regulation of virulence and exoproteases.
AdipoGen Quinidine anhydrous
Chemical. CAS 56-54-2. Formula C20H24N2O2. MW BD9837. Quinidine is a dextrorotatory stereoisomer of Quinine with anti-malarial, anti-arrhythmic class 1A, anti-inflammatory, anti-cancer and anti-viral properties. Quinidine acts as a blocker of voltage-gated sodium channels. Inhibition of the Nav1.5 channel is specifically involved in its anti-arrhythmic effects as a class I anti-arrhythmic agent. Quinidine also blocks certain voltage-gated potassium channels e.g. Kv1.4, Kv4.2, hERG, among others, acts as an anti-muscarinic. Quinidine blocks alpha1-adrenoceptors alpha1ARs and is an inhibitor of cytochrome P450 and acetylcholinesterase.
AdipoGen Stains-all
Chemical. CAS 7423-31-6. Formula C30H27BrN2S2. Molecular Weight 559.6. Stains-all is a carbocyanine dye, which stains anionic proteins, nucleic acids, anionic polysaccharides and other anionic molecules. Stains-all is metachromatic and changes its color dependent on its contact to other molecules. The detection limit for phosphoproteins is below 1ng after one hour of staining, for anionic polysaccharides between 10 and 500ng. Highly anionic proteins are stained blue, proteoglycans purple and anionic proteins pink. RNA is stained blueish-purple with a detection limit of 90ng and DNA is stained blue with a detection limit of 3ng. Stains-all is light sensitive, therefore the staining is performed in the absence of light and photographed immediately. Staining of proteins can be improved by a subsequent silver stain.